CD223 (LAG-3) (blocking) (clone 11E3, anti-human, monkey

Decription:
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

Synonyms: Lymphocyte Activation Gene-3, FDC Protein, CD223

Clone: 1,10E+04

Isotype: Mouse IgG1

Immunogen: Recombinant human LAG-3.

Reactivity: human, monkey

Specificity: Recognizes human and monkey LAG-3.

Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.

Applications:
ELISA: (capture)
Functional Application: Inhibition
Immunocytochemistry
Immunohistochemistry: (frozen sections)
Immunoprecipitation: (10?g/ml)
Western Blot: (5?g/ml)

Working Dilution: Optimal conditions must be determined individually for each application.

Concentration: 0.5 mg/ml

Storage: 2-8C immediate use, or -20C (aliquote)