CD223 (LAG-3) (blocking) (clone17B4 ), anti-human

Decription:
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

Synonyms: Lymphocyte Activation Gene-3, FDC Protein, CD223

Clone: 17B4

Isotype: Mouse IgG1

Immunogen: Synthetic peptide corresponding to 30 aa in the N-terminus of human LAG-3.

Reactivity: human

Specificity: Recognizes human LAG-3.

Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.

Applications:
Functional Application: Inhibition Immunocytochemistry
Immunohistochemistry: (frozen sections (1:150)) Immunoprecipitation: (10?g/ml)
Western Blot: (5?g/ml)

Working Dilution: Optimal conditions must be determined individually for each application.

Concentration: 1mg/ml

Storage: 2-8C immediate use, or -20C (aliquote)