CD227 (Episialin, EMA) (clone GP1.4), anti-human
€354.00
In stock
SKU
ARP-10-M1039
Catalog Number: 10-M1039
Size: 100 µg
Isotype: Mouse IgG1
Size: 100 µg
Isotype: Mouse IgG1
Background:
MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1(EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type I transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells.
Decription:
Mouse IgG monoclonal antibody for Episialin, EMA, mucin 1, cell surface associated (MUC1) detection. Tested with IHC-P, IHC-F in Human. No cross reactivity with other proteins.
Synonyms: CD227, EMA, PEM, PEMT, KL-6, PUM, MUCIN 1, URINARY, Episialin, H23AG, PEANUT-REACTIVE URINARY MUCIN, MUCIN, TUMOR-ASSOCIATED EPITHELIAL, POLYMORPHIC EPITHELIAL MUCIN, EPITHELIAL MEMBRANE ANTIGEN, mucin 1, transmembrane, Breast carcinoma-associated antigen DF3, Carcinoma-associated mucin, Krebs von den Lungen-6, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin
Clone: GP1.4
Isotype: Mouse IgG1
Immunogen: Human milk fat globule membranes.
Reactivity: human
Form: Lyophilized; Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
Applications: IHC-P, IHC-F
Reconstitution: Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.
MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1(EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type I transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells.
Decription:
Mouse IgG monoclonal antibody for Episialin, EMA, mucin 1, cell surface associated (MUC1) detection. Tested with IHC-P, IHC-F in Human. No cross reactivity with other proteins.
Synonyms: CD227, EMA, PEM, PEMT, KL-6, PUM, MUCIN 1, URINARY, Episialin, H23AG, PEANUT-REACTIVE URINARY MUCIN, MUCIN, TUMOR-ASSOCIATED EPITHELIAL, POLYMORPHIC EPITHELIAL MUCIN, EPITHELIAL MEMBRANE ANTIGEN, mucin 1, transmembrane, Breast carcinoma-associated antigen DF3, Carcinoma-associated mucin, Krebs von den Lungen-6, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin
Clone: GP1.4
Isotype: Mouse IgG1
Immunogen: Human milk fat globule membranes.
Reactivity: human
Form: Lyophilized; Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
Applications: IHC-P, IHC-F
Reconstitution: Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.
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