CD227 (MUC-1) (clone 214D4), anti-human
€564.00
In stock
SKU
ARP-21-5211
Catalog Number: 21-5211
Size: 100 µg
Isotype: Mouse IgG1
Size: 100 µg
Isotype: Mouse IgG1
Background:
Mucin 1, cell surface associated (MUC-1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in Humans. MUC-1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with colon, breast, ovarian, lung and pancreatic cancers.
Clone: 214D4
Isotype: Mouse IgG1
Source: 214D4 is a Mouse monoclonal IgG1 antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with a fusion protein, Human b-gal-episialin/MUC1 repeat domain.
Reactivity: human
Specificity: 214D4 is directed anti the repeat domain of episialin.
Form: Each vial contains 100ul purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applications: Flow Cytometry, Immunohistochemistry (frozen), Immunohistochemistry (paraffin)
Storage: Store at 4C, or in small aliquots at -20C.
Mucin 1, cell surface associated (MUC-1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in Humans. MUC-1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with colon, breast, ovarian, lung and pancreatic cancers.
Clone: 214D4
Isotype: Mouse IgG1
Source: 214D4 is a Mouse monoclonal IgG1 antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with a fusion protein, Human b-gal-episialin/MUC1 repeat domain.
Reactivity: human
Specificity: 214D4 is directed anti the repeat domain of episialin.
Form: Each vial contains 100ul purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applications: Flow Cytometry, Immunohistochemistry (frozen), Immunohistochemistry (paraffin)
Storage: Store at 4C, or in small aliquots at -20C.
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