CD227 (MUC1) polyclonal, anti-human

Quantity: 100 µg

Background:
Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans. This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. It is mapped to 1q22. Mucin 1 is a transmembrane mucin normally expressed on the apical borders of secretory epithelial cells. Overexpression of Mucin 1 is often associated with colon, breast, ovarian, lung and pancreatic cancers. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Mucin 1 stimulated ESR1-mediated transcription and contributed to estradiol-mediated growth and survival of breast cancer cells. This gene also can suppress pulmonary innate immunity, and its antiinflammatory activity may play an important modulatory role during microbial infection.

Description:
Rabbit IgG polyclonal antibody for Mucin-1 (MUC1) detection. Tested with IHC-P in Human.

Synonyms:
ADMCKD antibody, ADMCKD1 antibody, Breast carcinoma associated antigen DF3 antibody, Breast carcinoma-associated antigen DF3 antibody, CA 15-3 antibody, CA15 3 antibody, CA15 3 antigen antibody, CA15.3 antibody, Cancer antigen 15-3 antibody, Carcinoma associated mucin antibody, Carcinoma-associated mucin antibody, CD 227 antibody, CD227 antibody, DF3 antigen antibody, EMA antibody, Episialin antibody, H23 antigen antibody, H23AG antibody, KL 6 antibody, KL-6 antibody, KL6 antibody, Krebs von den Lungen-6 antibody, MAM 6 antibody, MAM6 antibody, MCD antibody, MCKD antibody, MCKD1 antibody, Medullary cystic kidney disease 1 (autosomal dominant) antibody, MUC 1 antibody, MUC-1 antibody, MUC-1/SEC antibody, MUC-1/X antibody, MUC1 antibody, MUC1-alpha antibody, MUC1-beta antibody, MUC1-CT antibody, MUC1-NT antibody, MUC1/ZD antibody, MUC1_HUMAN antibody, Mucin 1 antibody, Mucin 1 transmembrane antibody, Mucin 1, cell surface associated antibody, Mucin-1 subunit beta antibody, Peanut reactive urinary mucin antibody, Peanut-reactive urinary mucin antibody, PEM antibody, PEMT antibody, Polymorphic epithelial mucin antibody, PUM antibody, Tumor associated epithelial membrane antigen antibody, Tumor associated epithelial mucin antibody, Tumor associated mucin antibody, Tumor-associated epithelial membrane antigen antibody, Tumor-associated mucin antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human MUC1 recombinant protein (Position: R935-G1097). Human MUC1 shares 56% amino acid (aa) sequence identity with mouse MUC1.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.