CD239 Polyclonal Antibody

Background:
This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Cardiovascular, Immunology

Synonyms:
Antigen identified by monoclonal F8, AU, Auberger B antigen, B CAM cell surface glycoprotein, B cell adhesion molecule, B-CAM cell surface glycoprotein, Basal cell adhesion molecule (Lu and Au blood groups), Basal cell adhesion molecule (Lutheran blood group), Basal cell adhesion molecule, Basal cell adhesion molecule Lu and Au blood groups, Basal cell adhesion molecule Lutheran blood group, Bcam, BCAM, CD239, CD239 antigen, F8/G253 antigen, Glycoprotein 95kDa, LU, Lutheran, Lutheran antigen, Lutheran blood group (Auberger b antigen included), Lutheran blood group Auberger b antigen included, Lutheran blood group glycoprotein, MSK19

Immunogen: Recombinant protein of human BCAM

Swissprot: P50895
Gene Accession: BC050450

Calculated MW: 67 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-46795