CD240D (Rh D Blood Group antigen) (clone BRAD 5) Affinity Purified, anti-human

Decription:
Human Heterohybridoma to human Rh D/CD240D-Affinity purified. Human Heterohybridoma to human CD41-Culture supernatant.The Rh D antigen (Rh1 or Rho ) is clinically the most important of the Rh blood group system. It is expressed on the extracellular loops of a transmembrane polypeptide of around Mr 30000^.

Synonyms: Rh D blood group antigen, CD240

Clone: BRAD 5

Isotype: Human IgG1, kappa light chain

Immunogen: Human Rd D/CD240D

Reactivity: human. Estimated numbers of Rh D sites recognised by BRAD-5 on Rh D positive cells are between 12000 to 16000 on CDe/cde (R1r) cells and 28100 to 33900 on cDE/cDE (R2R2) cells^2. Rh D positive infants born to Rh D negative women may suffer from haemolytic disease of the newborn. The disease can be prevented by administration of anti-D post partum or antenatally. Dosage of anti-D depends on the size of feto-maternal hemorrhage (FMH). In humans the Rh D antigen is expressed solely on the erythrocytes of Rh D positive individuals. 85% of Caucasians are Rh D positive.

Form: Affinity purified, in 0.1 M glycine buffer, 1 M Tris buffer, pH 7.4, sterile filtered

Applications: Immunoblotting, Flow Cytometry, Immunofluorescence

Storage: 2-8C for immediate use, or at -20C (aliquot)

References:
1. Cartron, J-P, (1994) Blood Reviews 8, 199-212. 2. Jones J. et al, (1996) Vox Sanguinis 71, 176-183. 3. Kumpel B. et al, (1989) Br J Haematol 71, 125-129. 4. Kumpel B. et al, (1995) Blood 86 1701-1709. 5. Jones J. et al, (1995) Transfusion Medicine 5, 171-184