CD25 (IL-2RA) polyclonal, anti-human

Quantity: 100 µg

Background:
IL2RA(Interleukin 2 receptor, alpha), also called IL2R, IL2R, Alpha Chain or CD25, is a protein that in humans is encoded by the IL2RA gene.The IL2RA gene is mapped on 10p15.1. IL2RA is composed of strand-swapped "sushi-like" domains, unlike the classical cytokine receptor fold. As a result of this domain swap, IL2RA uses a composite surface to dock into a groove on IL2 that also serves as a binding site for antagonist drugs.Homodimeric alpha chains(IL2RA) result in low-affinity receptor, while homodimeric beta(IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Infection by the protozoan Trypanosoma cruzi causes Chagas disease, characterized by a reduction in the amount of IL2RA expressed on the surface of immune cells. This leads to chronic immune suppression, becoming increasingly severe over the course of many years and ultimately resulting in death if left untreated.

Description:
Rabbit IgG polyclonal antibody for Interleukin-2 receptor subunit alpha (IL2RA) detection. Tested with WB, IHC-P in Human.

Synonyms:
CD25 antibody, IDDM10 antibody, IL 2 RA antibody, IL 2 receptor subunit alpha antibodyIL 2R alpha chain antibody, IL 2R subunit alpha antibody, IL-2 receptor subunit alpha antibody, IL-2-RA antibody, IL-2R subunit alpha antibody, IL2 RA antibody, IL2 Receptor alpha antibody, IL2 receptor subunit alpha antibody, IL2-RA antibody, IL2R alpha chain antibody, IL2R antibody, IL2R subunit alpha antibody, IL2RA antibody, IL2RA_HUMAN antibody, Interleukin 2 receptor alpha chain antibody, interleukin 2 receptor subunit alpha antibody, Interleukin 2 receptor, alpha antibody, Interleukin-2 receptor subunit alpha antibody, Ly 43 antibody, Ly43 antibody, OTTHUMP00000019030 antibody, OTTHUMP00000019031 antibody, OTTHUMP00000019032 antibody, p55 antibody, p55 chain antibody, T Cell Growth Factor Receptor antibody, TAC antigen antibody, TCGFR antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human IL2RA(39-57aa MAYKEGTMLNCECKRGFRR).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.