CD253 (TRAIL) (clone HS501), anti-human

Decription:
TNF-related apoptosis-inducing ligand (TRAIL; Apo2L;CD253; TNFSF10) is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to five distinct receptors: TRAIL-R1 (DR4; Apo2; CD261; TNFRSF10A), TRAIL-R2 (DR5; KILLER; TRICK2A; TRICK2B; CD262; TNFRSF10B), TRAIL-R3 (DcR1; LIT; TRID; CD263; TNFRSF10C), TRAIL-R4 (DcR2; TRUNDD; CD264; TNFRSF10D), and osteoprotegerin (OPG; OCIF; TNFRSF11B). Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signaling complex (DISC). .

Synonyms: Apo-2L, TNFSF10, CD253

Clone: HS501

Isotype: Mouse IgG1

Immunogen: Recombinant human TRAIL.

Reactivity: human

Specificity: Recognizes human TRAIL.

Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.

Applications: Western Blot: (1:1000)

Working Dilution: Optimal conditions must be determined individually for each application.

Concentration: 1 mg/ml

Storage: 2-8C immediate use, or -20C (aliquote)