CD254 polyclonal, anti-human, mouse, rat, dog, pig , bovine

Protein Family: Cellular Antigens, Cytokines

Pathway and Disease: Signaling Molecules and Interaction, Development and Behavior, Immune System

Description:
Tumor necrosis factor ligand superfamily member 11 (CD254) is a cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. CD254 augments the ability of dendritic cells to stimulate naive T-cell proliferation. CD254 is an important regulator of interactions between T-cells and dendritic cells and plays a role in the regulation of the T-cell-dependent immune response. CD254 also plays a role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Defects in CD254 are the cause of osteopetrosis autosomal recessive type 2 (OPTB2), also known as osteoclast-poor osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone.

Alternate Names: RANKL, Osteoprotegerin ligand, OPGL, Tumor necrosis factor ligand superfamily 11, Receptor activator of nuclear factor kappa B ligand, TNF-related activation-induced cytokine, TRANCE, Osteoclast differentiation factor, ODF, CD254

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: O14788

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD254.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.