CD257 (BAFF) polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
BAFF was regularly detected by enzyme-linked immunosorbent assay in brain tissue lysates and in normal spinal fluid, and in astrocytes by double fluorescence microscopy. BAFF was localized in astrocytes close to BAFF-R-expressing immune cells. BAFF receptors were strongly expressed in situ in primary central nervous system(CNS) lymphomas. The TNF superfamily member B cell-activating factor(BAFF) plays an important role in humoral immunity and in autoimmune diseases, including RA.Local BAFF gene targeting inhibited proinflammatory cytokine expression, suppressed generation of plasma cells and Th17 cells, and markedly ameliorated joint pathology. The B cell activating factor BAFF(BlyS/TALL-1/zTNF4) is a tumor necrosis factor(TNF)-related ligand that promotes B cell survival and binds to three receptors(BCMA, TACI, and the recently described BAFF-R). Human BAFF was mapped to chromosome 13q32-34.4. The standard used in this kit is recombinant soluble human BAFF(A134-L295) with the molecular mass of 19.6KDa.

Description:
Rabbit IgG polyclonal antibody for Tumor necrosis factor ligand superfamily member 13B (TNFSF13B) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
ApoL related ligand TALL 1 antibody, B cell Activating Factor antibody, B cell Activating Factor antibody, B lymphocyte stimulator antibody, B-cell-activating factor antibody, BAFF antibody, BLYS antibody, CD 257 antibody, CD257 antibody, CD257 antigen antibody, delta BAFF antibody, Dendritic cell derived TNF like molecule antibody, Dendritic cell-derived TNF-like molecule antibody, DTL antibody, DTL precursor antibody, PRO738 antibody, soluble form antibody, TALL 1 antibody, TALL-1 antibody, TALL1 antibody, THANK antibody, TN13B_HUMAN antibody, TNF and APOL related leukocyte expressed ligand 1 antibody, TNF homolog that activates apoptosis antibody, TNF homolog that activates apoptosis NKFB and JNK. antibody, TNF- and APOL-related leukocyte expressed ligand 1 antibody, TNFSF13B antibody, TNFSF20 antibody, Tumor necrosis factor ligand superfamily member 13B antibody, Tumor necrosis factor ligand superfamily member 20 antibody, Tumor necrosis factor like protein ZTNF4 antibody, Tumor necrosis factor superfamily member 13B antibody, UNQ401 antibody, ZTNF4 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human BAFF(265-285aa RENAQISLDGDVTFFGALKLL), different from the related rat and mouse sequences by three amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse.
Predicted to work with: rat.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.