CD26 polyclonal, anti-human, mouse, rat

Background:
CD26 (dipeptidylpeptidase 4, adenosine deaminase complexing protein 2, ADABP, ADCP2, DPPIV, TP103) is a membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. CD26 has an essential role in immune regulation as a T cell activation molecule and a regulator of chemokine function. CD26 associates with CXCR4 and gp120 and may influence the pathophysiology of HIV infection. Adenosine deaminase (ADA) colocalizing with adenosine receptors on dendritic cells are able to interact with CD26 expressed on lymphocytes. This costimulatory signal in the immunological synapse leads to an increase in the production of the T helper 1 and proinflammatory cytokines IFN-gamma, TNF-alpha, and IL-6. CD26 plays a role in the pathogenesis and behavior of human cancers, including solid tumors and hematological malignancies. CD26-caveolin-1 interaction plays a role in the up-regulation of CD86 on TT-loaded monocytes and subsequent engagement with CD28 on T cells, leading to antigen-specific T cell activation.

Alternative Name:
ADCP-2, DPP IV, DPP4, CD26 antigen, ADA-binding protein, ADABP, ADCP 2, ADCP-2, ADCP2, Adenosine deaminase complexing protein 2, CD 26, CD26, CD26 antigen 3, Dipeptidyl peptidase 4, Dipeptidyl peptidase 4 soluble form, Dipeptidyl peptidase IV, Dipeptidyl peptidase IV membrane form, Dipeptidyl peptidase IV soluble form, Dipeptidyl peptidase, intestinal, Dipeptidylpeptidase 4, Dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2), Dipeptidylpeptidase IV, DPP 4, DPP IV, DPP IV estoenzyme, DPP4, DPP4, DPPIV, Intestinal dipeptidyl peptidase, T cell activation antigen CD26, T-cell activation antigen CD26, TP 103, TP103,

Application Dilution:
WB:1:500-1:2,000
ICC:1:50-1:200
IHC:1:50-1:100
FC:1:50-1:100

Specificity: CD26 polyclonal antibody detects endogenous levels of CD26 protein.

Immunogen:
recombinant protein

MW: 110 kDa

Swiss-Prot: P27487(Human) P28843(Mouse) P14740(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.