CD261 (DR4) polyclonal, anti-human

Quantity: 100 µg

Background:
TNFRSF10A(Tumor Necrosis Factor Receptor Subfamily Member 10A), also known as APO2, DR4 or TRAILR1, is a protein that in humans is encoded by the TNFRSF10A gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. By analysis of radiation hybrids, Marsters et al.(1997) mapped the DR4 gene to 8p21. The TRAIL receptor DR5, and 2 decoy receptors for TRAIL, DCR1, and DCR2, are located in the same region, suggesting that these receptors arose from recent gene duplication events. Pan et al.(1997) found that, as with FAS, TNFR1, and DR3, overexpression of DR4 induced apoptosis. However, unlike the other 3 death receptors, DR4 did not use FADD to transmit the death signal, suggesting the use of distinct proximal signaling machinery.

Description:
Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) detection. Tested with WB in Human.

Synonyms:
Apo 2 antibody, Apo2 antibody, CD 261 antibody, CD261 antibody, CD261 antigen antibody, Cytotoxic ligand TRAIL receptor antibody, Cytotoxic TRAIL receptor antibody, Death receptor 4 antibody, DR 4 antibody, DR4 antibody, MGC9365 antibody, NF related apoptosis-inducing ligand receptor 1 antibody, T10A antibody, TNF related apoptosis inducing ligand receptor 1 antibody, TNF-related apoptosis-inducing ligand receptor 1 antibody, TNFRSF10A antibody, TR10A_HUMAN antibody, TRAIL R1 antibody, TRAIL receptor 1 antibody, TRAIL-R1 antibody, TRAILR 1 antibody, TRAILR1 antibody, Tumor necrosis factor receptor superfamily member 10a antibody, Tumor necrosis factor receptor superfamily member 10A precursor antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human DR4(110-125aa TIKLHDQSIGTQQWEH).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.