CD261 (TRAIL-R1) (clone HS101), anti-human

Decription:
TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.

Synonyms: TRAIL Receptor 1, DR4, APO2, TNFRSF10A, CD261

Clone: HS101

Isotype: Mouse IgG1

Immunogen: Recombinant human TRAIL-R1 (DR4).

Reactivity: human

Specificity: Recognizes human TRAIL-R1. Does not cross-react with human TRAIL-R2, -R3 or -R4.

Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.

Applications:
Flow Cytometry
Functional Application: Inhibition (blocks TRAIL-R1 mediated killing if applied in solution).
Immunocytochemistry
Immunoprecipitation

Working Dilution: Optimal conditions must be determined individually for each application.

Concentration: 1mg/ml

Storage: 2-8C immediate use, or -20C (aliquote)