CD262 (DR5, Apo2, TRAIL-R2, TRICK2, KILLER) polyclonal, anti-human

Quantity: 100 µg

Background:
TNFRSF10B(Tumor necrosis factor receptor superfamily, member 10b) is a human gene. It is also known as DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5. The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand(TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b, that has been essential in the elucidation of the function of this gene in humans. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.By analysis of radiation hybrid panels, Walczak et al.(1997) mapped the TRAILR2 gene to chromosome 8p22-p21. Northern blot analysis indicated that TRAILR2 was expressed as a 4.4-kb mRNA in all tissues tested, with the highest levels of expression in peripheral blood lymphocytes, spleen, and ovary.

Description:
Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) detection. Tested with WB, IHC-P in Human.

Synonyms:
Fas like protein antibody, Apoptosis inducing protein TRICK2A/2B antibody, Apoptosis inducing receptor TRAIL R2 antibody, CD262 antibody, CD262 antigen antibody, Cytotoxic TRAIL receptor 2 antibody, Death domain containing receptor for TRAIL/Apo 2L antibody, Death receptor 5 antibody, DR5 antibody, KILLER antibody, KILLER/DR5 antibody, OTTHUMP00000123492 antibody, OTTHUMP00000123493 antibody, p53 regulated DNA damage inducible cell death receptor(killer) antibody, TNF related apoptosis inducing ligand receptor 2 antibody, TNF-related apoptosis-inducing ligand receptor 2 antibody, TNFRSF10B antibody, TR10B_HUMAN antibody, TRAIL R2 antibody, TRAIL receptor 2 antibody, TRAIL-R2 antibody, TRAILR2 antibody, TRICK2 antibody, TRICK2A antibody, TRICK2B antibody, TRICKB antibody, Tumor necrosis factor receptor like protein ZTNFR9 antibody, Tumor necrosis factor receptor superfamily member 10B antibody, Tumor necrosis factor receptor superfamily, member 10b antibody, ZTNFR9 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human DR5(333-348aa DPTETLRQCFDDFADL).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.