CD262 (TRAIL-R2) (clone TR2.21), anti-human

Decription:
TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.

Synonyms: TRAIL Receptor 2, DR5, KILLER, TNFRSF 10B, CD262

Clone: TR2.21

Isotype: Mouse IgG1

Immunogen: Recombinant human TRAIL-R2 (DR5).

Reactivity: human

Specificity: Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4.

Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.

Applications:
Flow Cytometry
Immunohistochemistry: (paraffin sections) (20?g/ml)
Western Blot: (1?g/ml)

Working Dilution: Optimal conditions must be determined individually for each application.

Concentration: 1mg/ml

Storage: 2-8C immediate use, or -20C (aliquote)