CD272 (W153) polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS9212
Background:
B and T lymphocyte attenuator (BTLA,CD272) is an immunoglobulin domain-containing glycoprotein whose expression is induced during T cell activation. BTLA is similar to CTLA-4 and PD-1, all of which are co-inhibitory receptors belonging to the CD28 family. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family counter receptors. Rather, the herpesvirus entry mediator (HVEM), a TNF receptor, acts as a molecular switch that modulates T cell activation by propagating inhibitory signals through BTLA. The BTLA-HVEM interaction is conserved between mouse and human, suggesting that this system is an important pathway regulating lymphocyte activation.
Alternative Name:
B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein, CD272, BTLA
Application Dilution: WB: 1:500~1:1000
Specificity: CD272 (W153) polyclonal antibody detects endogenous levels of CD272 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 120-176 of Human CD272.
MW: ~ 33 kDa
Swis Prot.: Q7Z6A9
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
B and T lymphocyte attenuator (BTLA,CD272) is an immunoglobulin domain-containing glycoprotein whose expression is induced during T cell activation. BTLA is similar to CTLA-4 and PD-1, all of which are co-inhibitory receptors belonging to the CD28 family. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family counter receptors. Rather, the herpesvirus entry mediator (HVEM), a TNF receptor, acts as a molecular switch that modulates T cell activation by propagating inhibitory signals through BTLA. The BTLA-HVEM interaction is conserved between mouse and human, suggesting that this system is an important pathway regulating lymphocyte activation.
Alternative Name:
B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein, CD272, BTLA
Application Dilution: WB: 1:500~1:1000
Specificity: CD272 (W153) polyclonal antibody detects endogenous levels of CD272 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 120-176 of Human CD272.
MW: ~ 33 kDa
Swis Prot.: Q7Z6A9
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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