CD274 (PD-L1) polyclonal, anti-human

Quantity: 100 µg

Background:
Programmed death-ligand 1 (PD-L1) also known as CD274 or B7-H1 is a protein that in humans is encoded by the CD274 gene. It is mapped to 9p24.1. PD-L1 is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. It has been concluded that upregulation of PD-L1 on tumor MDCs downregulates T-cell immunity and that PD-L1 blockade may represent an approach for cancer immunotherapy. PD-L1 can provide positive costimulatory signals for innate and adaptive immunity and for protection against intracellular bacterial infection. What’s more, It has been found that PD1/PDL1 pathway may be a good target for restoring antitumor immunity in ovarian cancer.

Description:
Rabbit IgG polyclonal antibody for Programmed cell death 1 ligand 1 (CD274) detection. Tested with WB in Human.

Synonyms:
B7 H antibody, B7 H1 antibody, B7 homolog 1 antibody, B7-H1 antibody, B7H antibody, B7H1 antibody, CD 274 antibody, CD274 antibody, Cd274 antibody, CD274 antigen antibody, CD274 molecule antibody, MGC142294 antibody, MGC142296 antibody, OTTHUMP00000021029 antibody, PD L1 antibody, PD-L1 antibody, PD1L1_HUMAN antibody, PDCD1 ligand 1 antibody, PDCD1L1 antibody, PDCD1LG1 antibody, PDL 1 antibody, PDL1 antibody, Programmed cell death 1 ligand 1 antibody, Programmed death ligand 1 antibody, RGD1566211 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human PD-L1 recombinant protein (Position: E45-T290). Human PD-L1 shares 69% amino acid (aa) sequence identity with mouse PD-L1.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.