CD279 (PD1) polyclonal, anti-human, rat

Quantity: 100 µg

Background:
PDCD1(Programmed cell death 1), also called PD1, encodes a cell surface receptor that is a member of the B7 superfamily involved in immunomodulation. This gene is mapped to 2q37.3. PDCD1 acts as an inhibitory molecule on T cells after interacting with its ligands PDL1 and PDL2. The PDCD1 gene contains 5 exons. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. Using flow cytometric analysis, It has been found that expression of PDCD1 was upregulated on CD16-positive and CD16-negative monocytes, but not on dendritic cells, in viremic HIV-positive patients, but not in highly active antiretroviral therapy (HAART)-treated HIV-positive patients. PDCD1 upregulation in monocytes was induced by microbial Toll-like receptor ligands and inflammatory cytokines.

Description:
Rabbit IgG polyclonal antibody for Programmed cell death protein 1 (PDCD1) detection. Tested with WB in Human, Rat.

Synonyms:
CD279 antibody, CD279 antigen antibody, hPD l antibody, hPD-1 antibody, hSLE1 antibody, PD 1 antibody, PD-1 antibody, PD1 antibody, PDCD 1 antibody, PDCD1 antibody, PDCD1_HUMAN antibody, Programmed cell death 1 antibody, Programmed cell death protein 1 antibody, Protein PD 1 antibody, Protein PD-1 antibody, SLEB2 antibody, Systemic lupus erythematosus susceptibility 2 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human PD1 recombinant protein (Position: P101-L288). Human PD1 shares 59% amino acid (aa) sequence identity with mouse PD1.E.coli-derived human PD1 recombinant protein (Position: P101-L288). Human PD1 shares 59% amino acid (aa) sequence identity with mouse PD1.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.