CD284 Polyclonal Antibody

Background:
TLR4, also named as CD284, belongs to the Toll-like receptor family. TLR4 cooperates with LY96 and CD14 to mediates the innate immune response to bacterial lipopolysaccharide (LPS). TLR4 acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

Research Area: Cancer, Cardiovascular, Immunology, Microbiology

Synonyms:
ARMD10, CD284, CD284 antigen, Homolog of Drosophila toll, hToll, TLR 4, TLR4, TLR4, TOLL, Toll like receptor 4, Toll-like receptor 4

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse TLR4.

Swissprot: O00206,Q9QUK6,Q9QX05

Calculated MW: 95 kDa
Observed MW: 95 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 0.9 mg/mL
Dilution: WB 1:500-1:2000, IHC 1::500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.