CD285 (TLR5) polyclonal, anti-human, mouse, rat
€422.00
In stock
SKU
251565
Catalog Nr.: 251565
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC, IP
Datasheet
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Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC, IP
Datasheet
Request Information
Protein Family: Cellular Antigens, Receptors and Channels
Pathway and Disease: Immune System, Infectious Diseases
Description:
Toll-like receptor 5 (TLR5) participates in the innate immune response to microbial agents. TLR5 mediates detection of bacterial flagellins. TLR5 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Individuals with a common stop codon polymorphism in position 392 are unable to mediate flagellin signaling. This polymorphism acts in a dominant fashion and is associated with susceptibility to pneumonia caused by Legionella pneumophila. Genetic variations in TLR5 are associated with resistance to systemic lupus erythematosus type 1 (SLEB1). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis.
Alternate Names: TLR5, CD285, Toll-like receptor 5, Toll/interleukin-1 receptor-like protein 3, TIL3
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IP: 1:100-1:500
Accession No.: O60602
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human TLR5.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Immune System, Infectious Diseases
Description:
Toll-like receptor 5 (TLR5) participates in the innate immune response to microbial agents. TLR5 mediates detection of bacterial flagellins. TLR5 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Individuals with a common stop codon polymorphism in position 392 are unable to mediate flagellin signaling. This polymorphism acts in a dominant fashion and is associated with susceptibility to pneumonia caused by Legionella pneumophila. Genetic variations in TLR5 are associated with resistance to systemic lupus erythematosus type 1 (SLEB1). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis.
Alternate Names: TLR5, CD285, Toll-like receptor 5, Toll/interleukin-1 receptor-like protein 3, TIL3
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IP: 1:100-1:500
Accession No.: O60602
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human TLR5.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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