CD288 (TLR8) polyclonal, anti-rat, mouse

Quantity: 100 µg

Background:
TLR8(Toll-like receptor 8) is a protein that in humans is encoded by the TLR8 gene. TLR8 has also been designated as CD288(cluster of differentiation 288). The TLR8 gene is mapped to Xp22.3-p22.2 by Chuang and Ulevitch(2000) and Du et al.(2000). The protein encoded by this gene is a member of the Toll-like receptor(TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns(PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. TLR8 recognises G-rich oligonucleotides.

Description:
Rabbit IgG polyclonal antibody for Toll-like receptor 8 (TLR8) detection. Tested with WB in Rat, Mouse.

Synonyms:
CD 288 antibody, CD288 antibody, CD288 antigen antibody, MGC119599 antibody, MGC119600 antibody, TLR 8 antibody, Tlr8 antibody, TLR8_HUMAN antibody, Toll Like Receptor 8 antibody, Toll-like receptor 8 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of rat TLR8(1013-1029aa ENDSRYDNLYIDSIRQY), different from the related mouse sequence by one amino acid.A synthetic peptide corresponding to a sequence at the C-terminus of rat TLR8(1013-1029aa ENDSRYDNLYIDSIRQY), different from the related mouse sequence by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: rat.
Predicted to work with: mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.