CD290 (TLR10) polyclonal, anti-human

Quantity: 100 µg

Background:
TLR10(Toll-like receptor 10), is a protein that in humans is encoded by the TLR10 gene. The protein encoded by this gene is a member of the Toll-like receptor(TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. By genomic sequence analysis, Hasan et al.(2005) determined that the TLR10 gene is clustered with TLR1 and TLR6 on chromosome 4p14. By coimmunoprecipitation analysis, Hasan et al.(2005) found that TLR10 associated with itself and with TLR1 and TLR2, but not with MD2. Signaling studies showed that TLR10 required MYD88, but not TIRAP, TRAM(TICAM2), or TRIF(TICAM1), to activate immune system promoters. Pro674 within the TLR10 TIR domain was required to activate all promoter examined.

Description:
Rabbit IgG polyclonal antibody for Toll-like receptor 10 (TLR10) detection. Tested with WB in Human.

Synonyms:
CD 290 antibody, CD 290 antigen antibody, CD290 antibody, CD290 antigen antibody, MGC104967 antibody, MGC126398 antibody, MGC126399 antibody, OTTHUMP00000158729 antibody, OTTHUMP00000218162 antibody, TLR10 antibody, TLR10_HUMAN antibody, Toll like receptor 10 antibody, Toll-like receptor 10 antibody, UNQ315/PRO358 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human TLR10(88-102aa DLKTFEFNKELRYLD).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.