CD293 (BMPR1B) polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
BMPR1B(Bone Morphogenetic Protein Receptor Type IB), also known as ALK6, is a protein which in humans is encoded by the BMPR1B gene. BMPR1B is a member of the bone morphogenetic protein(BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine(threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. By analysis of a monochromosome hybrid mapping panel and by FISH, Astrom et al.(1999) mapped the BMPR1B gene to chromosome 4q22-q24. Ide et al.(1997) compared BMP receptor expression in normal and cancerous prostate tissues. While BMPR1A and BMPR2 were expressed at similar levels in all prostate tissues, BMPR1B was expressed at a significantly reduced level in cancerous prostate tissue.

Description:
Rabbit IgG polyclonal antibody for Bone morphogenetic protein receptor type-1B (BMPR1B) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
Activin receptor like kinase 6 antibody, Acvrlk6 antibody, ALK 6 antibody, ALK6 antibody, alk6tr antibody, BMP type-1B receptor antibody, BMPR IB antibody, BMPR-1B antibody, Bmpr1b antibody, BMPRIB antibody, BMR1B_HUMAN antibody, Bone morphogenetic protein receptor type 1B antibody, Bone morphogenetic protein receptor type IB antibody, Bone morphogenetic protein receptor type-1B antibody, BR 1b antibody, BR1b antibody, CDw 293 antibody, CDw293 antibody, CDw293 antigen antibody, CFK 43a antibody, CFK43a antibody, Serine/threonine receptor kinase antibody, zALK 6 antibody, zALK6 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human BMPR1B(145-160aa FCYFRYKRQETRPRYS), different from the related rat and mouse sequences by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human.
Predicted to work with: mouse, rat.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.