CD31 polyclonal, anti-human, mouse

Background:
PECAM-1 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte transmigration, angiogenesis, and integrin activation. CD31 is also expressed in certain tumors, including epithelioid hemangioendothelioma, epithelioid sarcoma-like hemangioendothelioma, other vascular tumors, histiocytic malignancies, and plasmacytomas. It is rarely found in some sarcomas, such as Kaposi's sarcoma and carcinomas. In immunohistochemistry, CD31 is used primarily to demonstrate the presence of endothelial cells in histological tissue sections. This can help to evaluate the degree of tumour angiogenesis, which can imply a rapidly growing tumor

Alternative Name:
PECA1, CD31, Adhesion molecule, CD31, CD31 antigen, CD31 EndoCAM, EndoCAM, FLJ34100, FLJ58394, GPIIA, GPIIA', PECA1, PECA1, Pecam 1, PECAM 1 CD31 EndoCAM, PECAM, PECAM-1, Pecam1, Platelet and endothelial cell adhesion molecule 1, Platelet endothelial cell adhesion molecule, Platelet/endothelial cell adhesion molecule 1,

Application Dilution:
WB:1:1,000
ICC:1:200
IHC:1:200
FC:1:100-1:200

Specificity: CD31 polyclonal antibody detects endogenous levels of CD31 protein.

Immunogen:
This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to C-terminal residues of human CD31.

MW: 82 kDa (Observed: 130 kDa)

Swiss-Prot: P16284(Human) Q08481(Mouse)

Purification & Purity:
Peptide affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.