CD314 (NKG2D) (clone 1D11) Biotin, anti-human RUO

Introduction:

This activating receptor binds strongly to several ligands including MICA and MICB and ULBP-1, -2, and -3 proteins that are expressed by different target cell types. CD314 functions as a triggering receptor involved in natural cytotoxicity mediated by normal NK cells against a variety of tumors or normal target cells. Importantly, CD314 can complement the role of NCR in tumor cell lysis. Remarkably, the combined maskings of NCR and CD314 can reportedly lead to a complete inhibition of NK-mediated lysis of all tumor or normal cells

Recomended usage
CD314, clone ID11, is a mAb intended for the identification of NK cells, gamma delta T cells, CD8+ T cells, and some CD4+ T cells. This reagent is effective for direct IF staining of human tissue for FCM analysis using ≤1 μg/10^6 cells.

Application: FCM

Molecular Weight: 42 kDa

Storage Temperature: Store in the dark at 2-8 °C

Shelf life: Each reagent is stable until the expiration date shown on the bottle label when stored as directed (at least, one year)