CD320 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP13137b
Background:
The CD320 antigen gene encodes the transcobalamin receptor(TCBLR). Cellular uptake of cobalamin (vitamin B12) is mediated byreceptors expressed on the cell surface. Transcobalamin II (TCN2;MIM 613441), a plasma protein secreted by endothelial cells, bindsthe cobalamin absorbed in the distal ileum and carries 10 to 30% oftotal circulating cobalamin. CD320 encodes a transcobalaminreceptor that binds TCN2-cobalamin at the plasma membrane andinternalizes the complex by endocytosis (Quadros et al., 2009[PubMed 18779389]).
Other Names:
CD320 antigen, 8D6 antigen, FDC-signaling molecule 8D6, FDC-SM-8D6, Transcobalamin receptor, TCblR, CD320, CD320, 8D6A
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13137b was selected from the C-term region of CD320. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CD320
Gene ID: 51293
Primary Accession: Q9NPF0
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The CD320 antigen gene encodes the transcobalamin receptor(TCBLR). Cellular uptake of cobalamin (vitamin B12) is mediated byreceptors expressed on the cell surface. Transcobalamin II (TCN2;MIM 613441), a plasma protein secreted by endothelial cells, bindsthe cobalamin absorbed in the distal ileum and carries 10 to 30% oftotal circulating cobalamin. CD320 encodes a transcobalaminreceptor that binds TCN2-cobalamin at the plasma membrane andinternalizes the complex by endocytosis (Quadros et al., 2009[PubMed 18779389]).
Other Names:
CD320 antigen, 8D6 antigen, FDC-signaling molecule 8D6, FDC-SM-8D6, Transcobalamin receptor, TCblR, CD320, CD320, 8D6A
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13137b was selected from the C-term region of CD320. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CD320
Gene ID: 51293
Primary Accession: Q9NPF0
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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