CD324 (E-Cadherin) polyclonal, anti-human

Quantity: 100 µg

Background:
CDH1 (Cadherin 1), also known as ECAD or UVO, is a protein that in humans is encoded by the CDH1 gene. Cadherin-1 is a classical member of the cadherin superfamily. By Southern analysis of DNA from a panel of mouse-human somatic cell hybrids, Mansouri et al. (1987, 1988) assigned the UVO gene to 16q (16p11-qter). Frebourg et al. (2006) found that in human embryos CDH1 is highly expressed at 4 and 5 weeks in the frontonasal prominence and at 6 weeks in the lateral and medial nasal prominences, and is therefore expressed during critical stages of lip and palate development. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.

Description:
Rabbit IgG polyclonal antibody for Cadherin-1 (CDH1) detection. Tested with WB, IHC-P, IHC-F, ELISA in Human.

Synonyms:
Arc 1 antibody, CADH1_HUMAN antibody, Cadherin 1 antibody, cadherin 1 type 1 E-cadherin antibody, Cadherin1 antibody, CAM 120/80 antibody, CD 234 antibody, CD 324 antibody, CD324 antibody, CD324 antigen antibody, CDH1 antibody, CDHE antibody, E-Cad/CTF3 antibody, E-cadherin antibody, ECAD antibody, Epithelial cadherin antibody, epithelial calcium dependant adhesion protein antibody, LCAM antibody, Liver cell adhesion molecule antibody, UVO antibody, Uvomorulin antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human E Cadherin recombinant protein (Position: A286-A703). Human E Cadherin shares 79.7% and 80.9% amino acid (aa) sequence identity with mouse and rat E Cadherin, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P, IHC-F, ELISA

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.