AIM2 polyclonal, anti-human
€470.00
In stock
SKU
AC-AP68334
Background:
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Other Names:
AIM2; Interferon-inducible protein AIM2; Absent in melanoma 2
Antigen Type: synthetic peptide
Antigen Type: AIM2 {ECO:0000303|PubMed:9242382, ECO:0000312|HGNC:HGNC:357}
Gene ID: 9447
Primary Accession: O14862
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Other Names:
AIM2; Interferon-inducible protein AIM2; Absent in melanoma 2
Antigen Type: synthetic peptide
Antigen Type: AIM2 {ECO:0000303|PubMed:9242382, ECO:0000312|HGNC:HGNC:357}
Gene ID: 9447
Primary Accession: O14862
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