CD33 monoclonal, anti-human
€0.00
In stock
SKU
AC-AM2149b
Catalog Number: AC-AM2149b
Size: 80 µl, 400 µl
Isotype: mouse IgM
Clone Name: 574CT16.4.4
Applications: IF, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: mouse IgM
Clone Name: 574CT16.4.4
Applications: IF, WB
Datasheet
Request Information
Background:
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
Other Names:
Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, Siglec-3, gp67, CD33, CD33, SIGLEC3
Target/Specificity:
This CD33 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 337-364 amino acids from human CD33.
Antigen Region:
337-364
Antigen Type: Synthetic Peptide
Gene Name: CD33
Gene ID: 945
Primary Accession: P20138
NCBI Accession: NP_001076087.1;NP_001171079.1;NP_001763.3
Other Accession: NP_001763.3
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
Other Names:
Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, Siglec-3, gp67, CD33, CD33, SIGLEC3
Target/Specificity:
This CD33 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 337-364 amino acids from human CD33.
Antigen Region:
337-364
Antigen Type: Synthetic Peptide
Gene Name: CD33
Gene ID: 945
Primary Accession: P20138
NCBI Accession: NP_001076087.1;NP_001171079.1;NP_001763.3
Other Accession: NP_001763.3
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
| Is Featured? | No |
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