CD333 (FGFR3) polyclonal, anti-human, rat

Quantity: 100 µg

Background:
Fibroblast growth factor receptor 3, also known as CD333, is a protein that in humans is encoded by the FGFR3 gene. This gene encodes a member of the fibroblast growth factor receptor(FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. The FGFR3 gene is mapped to the HD region on chromosome 4p16.3. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.

Description:
Rabbit IgG polyclonal antibody for Fibroblast growth factor receptor 3 (FGFR3) detection. Tested with WB, IHC-P, ICC in Human, Rat.

Synonyms:
ACH antibody, CD 333 antibody, CD333 antibody, CD333 antigen antibody, CEK 2 antibody, CEK2 antibody, FGFR 3 antibody, FGFR-3 antibody, FGFR3 antibody, FGFR3_HUMAN antibody, Fibroblast growth factor receptor 3(achondroplasia thanatophoric dwarfism) antibody, Fibroblast growth factor receptor 3 antibody, Heparin binding growth factor receptor antibody, HSFGFR3EX antibody, Hydroxyaryl protein kinase antibody, JTK 4 antibody, JTK4 antibody, MFR 3 antibody, SAM 3 antibody, Tyrosine kinase JTK 4 antibody, Tyrosine kinase JTK4 antibody, Z FGFR 3 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human FGFR3(110-129aa RQRLTQRVLCHFSVRVTDAP), different from the related rat sequence by two amino acids, and from the related mouse sequence by three amino acids.A synthetic peptide corresponding to a sequence at the N-terminus of human FGFR3(110-129aa RQRLTQRVLCHFSVRVTDAP), different from the related rat sequence by two amino acids, and from the related mouse sequence by three amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat

Applications: WB, IHC-P, ICC

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.