CD34 (clone HPCA1/1806R), anti-human, rat

Background:
This antibody recognizes a transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. Its expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, it is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. CD34 expression is also found in vascular endothelium. Additionally, proliferating endothelial cells overexpress this molecule than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi s sarcoma, but shows low specificity.

Other Names:
Hematopoietic Progenitor Cell Antigen, HPCA1, Mucosialin

Antigen Type:
Recombinant protein

Gene Name: CD34
Gene ID: 947
Primary Accession: P28906
Other Accession: 374990