CD34 (Hematopoietic Stem Cell & Endothelial Marker) (clone SPM123 ), anti-human, rhesus, cynomolgus
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In stock
SKU
AC-AH10875
Catalog Number: AC-AH10875
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: SPM123
Applications: IHC-P, IF, FC
Datasheet
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Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: SPM123
Applications: IHC-P, IF, FC
Datasheet
Request Information
Background:
This MAb recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. On the basis of differential sensitivity to degradation by specific enzymes, epitopes of monoclonal antibodies to CD34 are classified intoĀthree main categories, class I, class II and class III. It is a class II antibody whose epitope is resistant to neuraminidase but sensitive to glycoprotease and chymopapain.ĀCD34 expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, CD34 is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. Its expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells express this molecule more than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposiā€™s sarcoma, but with a lower specificity.
Other Names:
Hematopoietic progenitor cell antigen CD34, CD34, CD34
Gene Name: CD34
Gene ID: 947
Primary Accession: P28906
Other Accession: 947, 374990
This MAb recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. On the basis of differential sensitivity to degradation by specific enzymes, epitopes of monoclonal antibodies to CD34 are classified intoĀthree main categories, class I, class II and class III. It is a class II antibody whose epitope is resistant to neuraminidase but sensitive to glycoprotease and chymopapain.ĀCD34 expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, CD34 is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. Its expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells express this molecule more than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposiā€™s sarcoma, but with a lower specificity.
Other Names:
Hematopoietic progenitor cell antigen CD34, CD34, CD34
Gene Name: CD34
Gene ID: 947
Primary Accession: P28906
Other Accession: 947, 374990
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