CD37 (Peripheral Mature B-Cell Marker) (clone IPO-24 ), anti-human
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In stock
SKU
AC-AH12730
Catalog Number: AC-AH12730
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: IPO-24
Applications: IF, FC
Datasheet
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Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: IPO-24
Applications: IF, FC
Datasheet
Request Information
Background:
Recognizes a protein of 33-55kDa, identified as CD37 (Workshop V; Code CD37.7). CD37 is strongly expressed on normal and neoplastic mature (sIg+) B-lymphocytes. In B-cell ontogeny, CD37 appears after the pre-B-cell stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells.1 CD37 is also present, at low densities, on resting and activated T cells, neutrophils, monocytes, and some myelomonocytic leukemia cells. It is absent from platelets, erythrocytes. CD37 is a member of a family of tetraspan transmembrane proteins, including CD9, CD53, CD63, CD81, and CD82. It associates other tetraspan transmembrane proteins and MHC class II molecules to form a large complex at the surface of B cells and play a role in signal transduction. CD37 is a valuable and stable marker for peripheral mature B-cells and corresponding malignancies like B-cell chronic lymphocytic leukemia (B-CLL), hairy cell leukemia (HCL), and all types of B-cell non-Hodgkin'ā€™ lymphoma (B-NHL).
Other Names:
Leukocyte antigen CD37, Tetraspanin-26, Tspan-26, CD37, CD37, TSPAN26
Gene Name: CD37
Gene ID: 951
Primary Accession: P11049
Other Accession: 951, 166556
Recognizes a protein of 33-55kDa, identified as CD37 (Workshop V; Code CD37.7). CD37 is strongly expressed on normal and neoplastic mature (sIg+) B-lymphocytes. In B-cell ontogeny, CD37 appears after the pre-B-cell stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells.1 CD37 is also present, at low densities, on resting and activated T cells, neutrophils, monocytes, and some myelomonocytic leukemia cells. It is absent from platelets, erythrocytes. CD37 is a member of a family of tetraspan transmembrane proteins, including CD9, CD53, CD63, CD81, and CD82. It associates other tetraspan transmembrane proteins and MHC class II molecules to form a large complex at the surface of B cells and play a role in signal transduction. CD37 is a valuable and stable marker for peripheral mature B-cells and corresponding malignancies like B-cell chronic lymphocytic leukemia (B-CLL), hairy cell leukemia (HCL), and all types of B-cell non-Hodgkin'ā€™ lymphoma (B-NHL).
Other Names:
Leukocyte antigen CD37, Tetraspanin-26, Tspan-26, CD37, CD37, TSPAN26
Gene Name: CD37
Gene ID: 951
Primary Accession: P11049
Other Accession: 951, 166556
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