CD38 polyclonal, anti-human

Background:
CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lymphocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabolites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance.

Alternative Name:
ADPRC 1, cADPr hydrolase 1, CD38, Acute lymphoblastic leukemia cells antigen CD38, ADP ribosyl cyclase 1, ADP ribosyl cyclase, ADP ribosyl cyclase/cyclic ADP-ribose hydrolase, ADP-ribosyl cyclase 1, ADPRC 1, ADPRC1, cADPr hydrolase 1, CD 38, CD38, CD38 antigen (p45), CD38 antigen, CD38 molecule, Cd38-rs1, CD38, CD38H, Cyclic ADP ribose hydrolase, Cyclic ADP ribose hydrolase 1, Cyclic ADP-ribose hydrolase 1, EC 3.2.2.5, Ecto nicotinamide adenine dinucleotide glycohydrolase, I-19, I19 (mouse), Lymphocyte differentiation antigen CD38, NAD(+) nucleosidase, NIM-R5 antigen, NIMR5 antigen (mouse), OTTHUMP00000158633, OTTHUMP00000217743, p45, T10,

Application Dilution:
WB:1:1,000
IHC:1:50-1:200

Specificity: CD38 polyclonal antibody detects endogenous levels of CD38 protein.

Immunogen:
recombinant protein

MW: 40/50 kDa

Swiss-Prot: P28907(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.