CD4 (clone Edu-2), anti-human

Background:
CD4 (Cluster of Differentiation 4) is a glycoprotein expressed on the surface of T helper cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the CD4 gene. CD4 plays a role in the recognition of foreign antigens presented to T cells by MHC class II molecules. Furthermore, this antigen acts as a receptor for HIV-1 by binding the viral protein gp120. The CD4 antigen is present on most thymocytes and a subpopulation of peripheral blood T cells, called T helper cells (Th). In addition, CD4 is expressed on monocytes and weak on macrophages.

Clone: Edu-2

Isotype: Mouse IgG

Source: Edu-2 is a mouse monoclonal IgG2a antibody raised against CD4.

Reactivity: human

Specificity: CD4 (Edu-2) recognizes the CD4 antigen (a 55 kD glycoprotein).

Form: Each vial contains 1 ml of 100ﾵg/ml purified monoclonal antibody in 0.01 M sodium phosphate, 0.15 M NaCl, 0.2% BSA, 0.09% sodium azide; pH 7.3.

Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (frozen), Immunohistochemistry (paraffin)

Storage: Store at 4C, or in small aliquots at -20C.