CD4 polyclonal, anti-human
€428.00
In stock
SKU
BS90243
Catalog Number: BS90243
Size: 100 µl
Other Size: 50 µl
Isotype: rabbit IgG
Applications: WB, FC
Questions? Contact us!
Size: 100 µl
Other Size: 50 µl
Isotype: rabbit IgG
Applications: WB, FC
Questions? Contact us!
Background:
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
Alternative Name:
CD4, CD 4, CD4 (L3T4), CD4, CD4 antigen (p55), CD4 antigen, CD4 molecule, CD4 receptor, CD4+ Lymphocyte deficiency, included, CD4, CD4mut, L3T4, Leu3, Ly-4, Lymphocyte antigen CD4, MGC165891, OTTHUMP00000238897, p55, T cell antigen T4, T cell antigen T4/LEU3, T cell differentiation antigen L3T4, T cell OKT4 deficiency, included, T cell surface antigen T4/Leu 3, T cell surface antigen T4/Leu3, T cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, W3/25, W3/25 antigen antibody
Application Dilution:
WB:1:500
FC:1:50-1:100
Specificity: CD4 polyclonal antibody detects endogenous levels of CD4 protein.
Immunogen:
Recombinant protein with Human CD4 1-300 aa.
MW: 51 kDa
Swiss-Prot: P01730 Human
Purification & Purity:
Protein affinity purified.
Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Storage:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
For research use only, not for use in diagnostic procedure.
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
Alternative Name:
CD4, CD 4, CD4 (L3T4), CD4, CD4 antigen (p55), CD4 antigen, CD4 molecule, CD4 receptor, CD4+ Lymphocyte deficiency, included, CD4, CD4mut, L3T4, Leu3, Ly-4, Lymphocyte antigen CD4, MGC165891, OTTHUMP00000238897, p55, T cell antigen T4, T cell antigen T4/LEU3, T cell differentiation antigen L3T4, T cell OKT4 deficiency, included, T cell surface antigen T4/Leu 3, T cell surface antigen T4/Leu3, T cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, W3/25, W3/25 antigen antibody
Application Dilution:
WB:1:500
FC:1:50-1:100
Specificity: CD4 polyclonal antibody detects endogenous levels of CD4 protein.
Immunogen:
Recombinant protein with Human CD4 1-300 aa.
MW: 51 kDa
Swiss-Prot: P01730 Human
Purification & Purity:
Protein affinity purified.
Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Storage:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
For research use only, not for use in diagnostic procedure.
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