CD40 (clone FGK45), anti-mouse

Decription:
CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.

Synonyms: Tumor Necrosis Factor Receptor Superfamily Member 5, CD40L Receptor

Clone: FGK45

Isotype: Rat IgG2a

Immunogen: Recombinant mouse CD40 fusion protein.

Reactivity: mouse

Specificity: Recognizes mouse CD40.

Form: Purified, in PBS containing 0.02% sodium azide.

Applications:
Flow Cytometry
Functional Application: Activates B and NK cells in vivo and in vitro. For in vivo studies use the preservative free antibody (Prod. No. AG-20B-0036PF).

Working Dilution: Optimal conditions must be determined individually for each application.

Concentration: 1mg/ml

Storage: 2-8C immediate use, or -20C (aliquote)