CD40L polyclonal, anti-human

Quantity: 100 µg

Background:
CD40 ligand(CD40L) is a type II membrane protein of 261 amino acids on activated T cells that induces B cell proliferation and immunoglobulin secretion. It has homology with tumour necrosis factor-alpha and -beta, and has important functions in B-cell activation and differentiation. Human CD40L with 5 exons, is mapped to the proximal region of the mouse X chromosome on Xq26.3-27.1, and can be detected on T cells but is absent from B cells and monocytes. Since CD40L is expressed on platelets and released from them on activation, its predictive value as a marker for clinical outcome and the therapeutic effect of inhibition of glycoprotein IIb /IIIa receptor in patients with acute coronary syndromes was investigated. The soluble CD40L may be involved in the process of restenosis and that it exerts its effect by triggering a complex group of inflammatory reactions on endothelial and mononuclear cells. CD40L plays a central role in the pathophysiology of acute coronary syndromes, and has a role in the pathogenesis of coronary artery lesions.

Description:
Rabbit IgG polyclonal antibody for CD40 ligand (CD40LG) detection. Tested with WB, IHC-P in Human.

Synonyms:
CD154 antibody, CD 40L antibody, CD154 antibody, CD154 antigen antibody, CD40 antigen ligand antibody, CD40 homologue antibody, CD40 L antibody, CD40 ligand antibody, CD40 ligand, soluble form antibody, CD40-L antibody, CD40L_HUMAN antibody, CD40LG antibody, gp39 antibody, hCD40L antibody, HIGM1 antibody, Hyper IgM syndrome antibody, IGM antibody, IMD3 antibody, Ly62 antibody, T B cell activating molecule antibody, T BAM antibody, T cell antigen GP39 antibody, T-cell antigen Gp39 antibody, TBAM antibody, TNF related activation protein antibody, TNF superfamily member 5 antibody, TNF-related activation protein antibody, Tnfsf5 antibody, TRAP antibody, Tumor Necrosis Factor(ligand) Superfamily Member 5 antibody, Tumor necrosis factor ligand superfamily member 5 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human CD40L(47-65aa HRRLDKIEDERNLHEDFVF), different from the related mouse sequence by three amino acids, rat sequence by four amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.