CD40L (Ruplizumab) (clone ), anti-human antibody
€655.00
In stock
SKU
AC-ABV11788-200
Catalog Number: AC-ABV11788-200
Size: 200 µg
Host: recombinant human IgG1 antibody
Applications: FC
Datasheet
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Size: 200 µg
Host: recombinant human IgG1 antibody
Applications: FC
Datasheet
Request Information
Background:
Cytokine that binds to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching. The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralizes CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the antibody was found to have a T1/2 of 531&thinsp, ± 155 hours.
Other Names:
CD40 ligand, tumour necrosis factor ligand superfamily member 5, TNFSF5, CD154, tumour necrosis factor related activation protein, TRAP
Primary Accession: P29965
Gene Name: CD40LG
Gene ID: 959
Cytokine that binds to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching. The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralizes CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the antibody was found to have a T1/2 of 531&thinsp, ± 155 hours.
Other Names:
CD40 ligand, tumour necrosis factor ligand superfamily member 5, TNFSF5, CD154, tumour necrosis factor related activation protein, TRAP
Primary Accession: P29965
Gene Name: CD40LG
Gene ID: 959
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