CD41/CD61 (clone PAB-1) PE, anti-human

Decription:
Mouse monoclonal antibody to human CD41/CD61 PE conjugate. The integrin alpha IIb chain interacts with the integrin beta 3 subunit (CD61) to form the platelet glycoprotein complex, GpIIb/IIIa. It is expressed on platelets and megakaryocytes. The CD41/CD61 complex appears early in megakaryocyte maturation. Ligands for the GpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The GpIIb/IIIa complex is the major integrin on platelets and is important for clot retraction, platelet adhesion and aggregation.

Synonyms: CD41/CD61, platelet glycoprotein complex, GpIIb/IIIa

Clone: PAB-1

Isotype: Mouse IgG1, kappa light chain

Immunogen: CD41/CD61 heterodimer protein.

Reactivity: human

Form: PE-conjugate, in PBS buffer, pH 7.2 containing 0.1% sodium azide, 1% BSA

Applications: Flow Cytometry, Immunofluorescence

Working Dilution: 2ul per test (may change from lot to lot)

Storage: 2-8C, do not freeze

References:
1. Sun QH, Newman PJ. CD guide. CD41. In: Kishimoto T, Kikutani H, von dem Borne AEG, Goyert SM, Mason DY, Miyasaka M, et al., editors. Leucocyte typing VI. White cell differentiation antigens. Proceedings of the 6th International Workshop and Conference; 1996 Nov 10-14; Kobe, Japan. New York, London: Garland Publishing Inc.; 1997. p. 1139.
2. Vinci G, Tabilio A, Deschamps JF, van Haeke D, Henri A, Guichard J, et al. Immunological study of in vitro maturation of human megakaryocytes. Br J Haematol 1984;56:589-605.
3. Campbell K, Rishi K, Howkins G, Gilby D, Mushens R, Ghevaert C, Metcalfe P, Ouwehand W, Lucas G (2007). A modified rapid monoclonal antibody-specific immobilisation of platelet antigen assay for the detection of human platelet antigens (HPA) antibodies: a multicentre evaluation. Vox Sanguinis, 93, 289-297.