CD41a (clone 96-2C1), anti-human

Source:
A BALB/c mouse was immunized with stimulated human PBL.
Fusion partner: NS-1.



Specifications:
96-2C1 reacts with a calcium-dependent complex of CD41/CD61 (GPIIb/IIIa; integrin IIa/3), a dimer of 90 and 140 kDa, present on the membrane of normal platelets and megakaryocytes. This complex forms the receptor of fibrinogen, fibronectin and Von Willebrand factor, and mediates platelet adhesion and aggregation. MAbs to CD41a have been shown to have anti-proliferative effects on various lymphoid cell lines, particularly those derived from large cell lymphomas. 96-2C1 was typed at the IIId HLDA workshop.

Species reactivity:
Positive: human.

Applications:
Demonstration of CD41a in frozen sections, flow cytometry and immunofluorescence.
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +

Positive control: KG1a, HEL cells, and human platelets in lymph nodes or tonsils.

References:
- McMichael et al. Leucocyte typing III. p. 744. Oxford Univ. Press. (1987)