CD43 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
CD43, also known as leukosialin or sialophorin, is a transmembrane cell surface protein that in humans is encoded by the SPN gene. It is mapped to 16p11.2. It is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which is important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation. Expression of CD43 is deficient and/or defective in the X-chromosome-linked immunodeficiency disorder Wiscott-Aldrich syndrome, suggesting that CD43 have a role in T-cell activation. T-cell activation requires the removal of CD43 from the immunologic synapse to allow efficient engagement of the TCR with molecules on the APC.

Description:
Rabbit IgG polyclonal antibody for Leukosialin (SPN) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.

Synonyms:
CD43 antibody, CD43 antibody, CD43 antigen antibody, Galactoglycoprotein antibody, Galactoglycoprotein antibody, GALGP antibody, GPL 115 antibody, GPL115 antibody, Human gene for sialophorin antibody, Leucocyte sialoglycoprotein antibody, Leucocyte sialoglycoprotein antibody, LEUK_HUMAN antibody, Leukocyte sialoglycoprotein antibody, Leukosialin antibody, LSN antibody, Sialophorin (leukosialin) antibody, Sialophorin antibody, SPN antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human CD43 recombinant protein (Position: A272-P400). Human CD43 shares 72% and 73% amino acid (aa) sequences identity with mouse and rat CD43, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P, ICC

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.