CD44 polyclonal, anti-human

Background:
Cell adhesion molecules (CAMs) are a family of closely related, cell surface glycoproteins that are involved in cell-cell interactions and are thought to play an important role in embryogenesis and development. HCAM, also known as CD44, LHR, MDU2, MDU3, MIC4, Pgp1, HCELL, MUTCH-I or ECMR-III, is a 742 amino acid single-pass type I membrane protein that is involved in hematopoiesis, lymphocyte activation and tumor metastasis. Functioning as a receptor for hyaluronic acid (HA) and interacting with ligands such as osteopontin (OPN), HCAM mediates both cell-cell and cell-matrix interactions, thereby playing an essential role in cell adhesion and cell migration. HCAM contains one Link domain and, due to alternative splicing events, is expressed as multiple isoforms, some of which are designated CD44R, CDw44, CD44S, CD44H (hematopoietic) and CD44E (epithelial). While most of the HCAM splice varients are expressed in tissues throughout the body, one specific isoform, namely CD44H, is expressed at high levels in cancer tissue, suggesting an important role for the CD44H splice varient in tumor progression.

Alternative Name:
ECMR-III, PGP-1, PGP-I, LHR, MDU2, MDU3, MIC4, LHR, BA-1, CD 44, CD44, CD44 antigen, CD44 molecule (Indian blood group), CD44 molecule, CD44, CDw44, Cell surface glycoprotein CD44, chondroitin sulfate proteoglycan 8, CSPG8, ECMR-III, Epican, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, HCELL, hematopoietic cell E- and L-selectin ligand, Heparan sulfate proteoglycan, Hermes antigen, homing function and Indian blood group system, HSA, HUTCH-I, HUTCH1, Hyaluronate receptor, IN, MC56, MDU2, MDU3, MGC10468, MIC4, MUTCH1, PGP-1, PGP-I, PGP1, Phagocytic glycoprotein 1, Phagocytic glycoprotein I, Soluble CD44,

Application Dilution:
WB:1:1,000-1:5,000
IHC:1:50-1:200
FC:1:50-1:100

Specificity: CD44 polyclonal antibody detects endogenous levels of CD44 protein.

Immunogen:
recombinant protein

MW: 82 kDa

Swiss-Prot: P16070(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.