CD45 (clone 3G4), anti-human

Background:
Mouse Monoclonal

Decription:
CD45 belongs to a family of heavily glycosylated, high molecular weight transmembrane glycoproteins expressed on all cells of haematopoietic origin. Structurally heterogeneous, CD45 consists of a family of eight isoforms ranging from 180,000 to 220,000 MW generated by alternative splicing of three exons differentially expressed on subpopulation of lymphocytes. CD45 protein tyrosine phosphatase activity plays a central role in T-cell activation. CD45 plays an important role in signal transduction inhibition or upregulation of various immunological functions,

Synonyms: protein tyrosine phosphatase, receptor type, C (PTPRC), CD45, B220, CD 45, CD45 antigen, GP180, L CA, LCA, Leukocyte common antigen, LY5, Protein tyrosine phosphatase receptor type C, Protein tyrosine phosphatase receptor type c polypeptide, PTPRC, SCID due to PTPRC deficiency, T200, T200 glycoprotein,

Clone: 3G4. Anti-human CD45 mAb, clone 3G4, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CD45 protein.

Isotype: IgG2a, k

Immunogen: Recombinant human CD45 (1029-1249aa) purified from E. coli

Reactivity: human

Form: Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

Applications: ELISA, WB (Cell lysate)

Working Dilution: Optimal dilution should be performed by user.

NCBI Nr.: NM_002838

Concentration: 0.1 mg/ml

Storage: Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.