CD45 (clone 8C1) mouse monoclonal, anti-human

Backgroud: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN . Dephosphorylates LYN, and thereby modulates LYN activity.

Synonyms: GP180, L CA, CD45 antigen

Gene Name: Ptprc

Gene ID: 19264

SwissProt ID: P06800

Purification: Affinity Purified

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.