CD46 polyclonal, anti-human, mouse, rat

Background:
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

Synonyms: AHUS2, MCP, MIC10, TLX, TRA2.10

Cellular Location: Cytoplasmic vesicle Single-pass type I membrane protein acrosome inner membrane secretory vesicle

Immunogen:
Recombinant protein of human CD46

Gene Symbol: CD46

Gene ID: 4179

Swiss prot: P15529

Calculated MW: 44kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.