CD47 Polyclonal Antibody

Background:
CD47,also known as integrin-associated protein (IAP),is a member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. CD47 is heavily glycosylated and widely expressed by hematopoietic and nonhematopoietic cells. CD47 interacts with several membrane integrins and also acts a receptor for thrombospondin (THBS1). It is involved in a range of cellular processes,including apoptosis,proliferation,adhesion,and migration. CD47 also functions as a ligand for signal regulatory protein-α (SIRPα). Upon binding CD47,SIRPα initiates a signaling cascade that results in the inhibition of phagocytosis.

Research Area: Cancer, Immunology

Synonyms:
Antigen identified by monoclonal antibody 1D8, Antigenic surface determinant protein OA3, CD 47, IAP, Integrin Associated Protein, Leukocyte surface antigen CD47, MER6, OA3, Protein MER6, Rh related antigen

Immunogen: Recombinant Mouse Leukocyte surface antigen CD47 protein

Swissprot: Q61735
Gene ID: 16423

Purification Method: Antigen Affinity Purification

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.