CD62P polyclonal, anti-human

Quantity: 100 µg

Background:
P-Selectin, also called CD62, GRMP, GMP140 is a 140-kD adhesion molecule, expressed at the surface of activated cells, that mediates the interaction of activated endothelial cells or platelets with leukocytes. The P-Selectin gene is mapped on 1q24.2. P-selectin plays an essential role in the initial recruitment of leukocytes(white blood cells) to the site of injury during inflammation. P-selectin is also very important in the recruitment and aggregation of platelets at areas of vascular injury. In quiescent platelet, P-selectin is located on the inner wall of alpha-granules. Sorting nexin-17 interacts with the cytosolic domain of P-selectin and suggested that SNX17 may function in the intracellular trafficking of P-selectin. P-selectin expression was found to be significantly and positively correlated with carotid artery stiffness and wall thickness, and the percentage of P-selectin-positive platelets was significantly higher in patients with carotid plaque.

Description:
Rabbit IgG polyclonal antibody for P-selectin (SELP) detection. Tested with WB, IHC-P in Human.

Synonyms:
Antigen CD62 antibody, CD62 antibody, CD62 antigen-like family member P antibody, CD62P antibody, CD62P antigen antibody, FLJ45155 antibody, GMP 140 antibody, GMP-140 antibody, GMP140 antibody, GMRP antibody, Granule membrane protein 140 antibody, Granule membrane protein 140kDa antibody, Granulocyte membrane protein antibody, GRMP antibody, LECAM 3 antibody, LECAM3 antibody, Leukocyte endothelial cell adhesion molecule 3 antibody, Leukocyte-endothelial cell adhesion molecule 3 antibody, LYAM3_HUMAN antibody, P Selectin antibody, P-selectin antibody, PADGEM antibody, Platelet activation dependent granule external membrane protein antibody, Platelet activation dependent granule-external membrane protein antibody, Platelet alpha granule membrane protein antibody, PSEL antibody, Selectin P(granule membrane protein 140kDa antigen CD62) antibody, Selectin P(granule membrane protein 140kDa, antigen CD62) antibody, SELP antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human CD62P(49-66aa KAYSWNISRKYCQNRYTD).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.