CD68 polyclonal, anti-human, bovine

Protein Family: Cell Adhesion Molecules, Cellular Antigens, Receptors and Channels

Pathway and Disease: Cancers, Cell Motility, Immune System

Description:
The CD68 antigen is involved in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 binds to tissue- and organ-specific lectins and selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane helps macrophages to move over selectin-bearing substrates and other cells. CD68 is highly expressed by blood monocytes and tissue macrophages as well as many tumor cell lines promoting binding to selectins on vascular endothelium facilitating dissemination to secondary sites.

Alternate Names: Macrosialin, Gp110, CD68

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: P34810

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD68.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1 mg/ml BSA, 25% glycerol with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.